Godfrey RW, Severs NJ, Jeffery PK (1992) Freeze-fracture morphology and quantification of human bronchial epithelial tight junctions. New insights into airway epithelial barrier function in health and disease. Rezaee F, Georas SN (2014) Breaking barriers. Georas SN, Rezaee F (2014) Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation. Schleimer RP, Kato A, Kern R, Kuperman D, Avila PC (2007) Epithelium: at the interface of innate and adaptive immune responses. In this article, the measurement of epithelial permeability in the respiratory tract will be discussed with in vitro, in vivo aspects and methods. Therefore, measuring the level of epithelial permeability in these units is important for understanding experimental models, disease cause, clinical severity, and prognosis. However, the increase in permeability exceeding the limit is the cause of the diseases and the increase in clinical weight. The epithelial barrier in the respiratory tract has to be semipermeable in places. The respiratory tract continues from the tip of the nose to the alveola. The two most important barriers that separate humans from nature and their microenvironment are the respiratory tract and the gastrointestinal system. However, the normal properties of this epithelial barrier may differ in each organ and tissue. It provides separation of living cells or organelles from nature and microenvironment. The epithelial barrier is the basic unit that ensures the continuation of life for all living things.
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